5 Best Weight Loss Supplements for Men (2021 Reviews)

5 Best Weight Loss Supplements for Men (2021 Reviews)

* If you’re unsure if weight loss supplements are right for you, talk with your primary healthcare provider.

(Ad) For men who want to lose weight and burn fat, there are a variety of weight loss pills to choose from. From appetite suppressants and fat burners to carb blockers, the options are limitless.

The best weight loss pills for men contain 100% natural ingredients that can help speed up your metabolism, suppress your appetite, and burn fat. 

But not every weight loss supplement is created equal and some diet pills don’t even work at all. Choosing the best weight loss pills can feel like a daunting task, especially when every fat burner claims to be the most effective. 

To help you find the best weight loss pill for your needs, we’ve reviewed the top diet pills on the market. We evaluated each diet supplement based on its ingredients, reviews, dosage, price, and refund policy.

If you’re looking to accelerate your weight loss journey, here are the best weight loss pills for men.

5 Best Weight Loss Pills for Men in 2021

#1 PhenQ: Highest Quality and Best Overall


PhenQ is our top choice for the best weight loss pill for men. PhenQ contains a trademarked formula called α-Lacys Reset® that ramps up thermogenesis, or your body’s ability to burn calories, which in turn fires up your metabolism. The manufacturer says this unique combination of ingredients can help users increase muscle and lose weight—plus, it helps your body burn fat. No wonder the manufacturer calls PhenQ the “ultimate, all-in-one weight loss pill.”

How it works

Some ingredients in PhenQ curb your appetite, which can make weight loss easier. While you burn off fat, other ingredients are designed to prevent your body from producing new fat cells. You won’t feel deprived or cranky either, the manufacturer says. This diet pill has “mood-enhancing properties” and “energy-boosting” ingredients to keep you running on an even keel.

Overview of formula

PhenQ contains caffeine, piperine, niacin (a B vitamin), and Capsimax powder, a blend of capsicum (from peppers). While all of these may crank up your body’s energy and trigger fat burning, PhenQ also has nopal cactus fiber, which might help reduce the weight gained from retaining fluids. 

Another amino acid and energy-booster, L-carnitine fumarate, is thought to battle the tiredness that some dieters feel. You can find L-carnitine fumarate naturally in nuts, green vegetables, and red meat.


  • Caffeine
  • L-carnitine fumarate
  • Chromium picolinate
  • Magnesium stearate
  • Nopal
  • Capsimax powder (a blend of caffeine, capsicum, niacin, and piperine)


Take two pills daily. The manufacturer says each PhenQ bottle contains sixty pills or one month’s supply.

Who should take this?

PhenQ is perfect for men that have trouble losing weight with diet and exercise alone. Since PhenQ boosts metabolism and suppresses appetite, it’s a powerful weight loss pill that gets results.

Click Here for the Lowest Price on PhenQ

#2 Instant Knockout: Best Thermogenic Fat Burner

instant knockout

Instant Knockout is our pick for a fat burner if you’re looking to build muscle while you lose weight and shed body fat. The manufacturers initially developed their formula for MMA fighters and pro boxers, who need to burn fat before competition. These athletes found Instant Knockout so successful that the manufacturers released it to the public.

Instant Knockout is an effective fat burner because it contains 10 fat-burning ingredients, including cayenne pepper and green tea extract. Also, pros such as MMA fighter Diego Sanchez (middleweight champion of The Ultimate Fighter: Season 1) and MMA coach Greg Jackson endorse it.

How it works

Your metabolism works when your body converts what you drink and eat into energy. Your body needs fuel for everything it does, even automatic functions such as breathing, repairing and growing cells, circulating blood, and so on. According to the Mayo Clinic, your body uses about 10% of the calories from the protein and carbohydrates you eat or drink to process, transport, and store your food.

Each of us has a basal metabolic rate, or the number of calories our bodies use to carry out basic functions. Instant Knockout, its manufacturer says, boosts your metabolism so that your body will store less fat and burn more reserve fat as energy. Its other ingredients reduce hunger pangs and keep you energized between meals.

Overview of formula

A key ingredient in Instant Knockout is green tea extract, which may increase your metabolic rate so that you burn calories through thermogenesis. This generates heat in tissues such as skeletal muscle, dissipating that extra energy. Additional ingredients such as capsaicin may also ramp up your metabolism and increase the energy you use, adding to the fat-burning process.

Absorption is important for any weight loss supplement, so Instant Knockout contains GTF chromium, which might help increase how the body regulates glucose, and piperine, to help digestion. To reduce cravings, Instant Knockout also contains the natural fiber glucomannan.


  • Green tea extract
  • Green coffee bean
  • Caffeine anhydrous
  • Cayenne pepper seeds (capsaicin)
  • GTF chromium
  • Piperine
  • Glucomannan
  • Vitamin B6
  • Vitamin B12
  • Zinc


For the best results, the manufacturer says to take one pill four times a day, continuing with your regular diet and exercise routine.

Who should take this?

Because athletes endorse it, we recommend that men who want to build muscle while they burn fat and drop pounds try this weight loss supplement.

Click Here for the Lowest Price on Instant Knockout

#3 Burn Lab Pro: Best for Men Over 40

burn lab pro

As we age, changes in our hormones and metabolism affect how we burn fat and lose weight. Burn Lab Pro combats a sluggish metabolism and age-related weight gain by helping you preserve and protect your muscle mass during workouts and also burn more fat and calories as you exercise.

How it works

The manufacturer says that Burn Lab Pro is an effective fat burner because it “supercharges three key pathways” that work together to produce lean muscle mass. MMA Bantamweight World Champion Aljamain “Funk Master” Sterling endorses it for helping him to drop weight before a match without taxing him physically and mentally.

Each calibrated ingredient is thought to help with a different need, , such as improving focus and clarity, increasing body heat and fat burning, and heightening energy balance so that you burn more calories, promoting maximum muscle growth and recovery, and controlling appetite.

Overview of formula

Burn Lab Pro uses five natural ingredients that complement each other to make its fat-burning properties top-notch, its manufacturer says. What’s more, unlike diet pills, weight loss supplements, or fat burners that rely on caffeine variants, Burn Lab Pro is stimulant-free.

Its top ingredient is ForsLean®, its proprietary blend of Coleus forskohlii, an Ayurvedic root herb also known as forskolin, which grows in Thailand, Nepal, and India. The Burn Lab Pro team says that when used with diet and exercise, ForsLean® “triggers a hormonal cascade” that boosts metabolic rate, fat burning, and muscle growth.

Full List of Ingredients

  • ForsLean® (Coleus forskohlii root)
  • Calcium
  • GTF chromium
  • HMB
  • Capsimax® (cayenne pepper extract)
  • BioPerine® (black pepper extract)


The manufacturer recommends taking two to four capsules 15 minutes before training for the best results.

Who should take this?

Burn Lab Pro is designed to support all weight loss programs that include regular exercise and a healthy diet, its manufacturer says. However, men over 40 who train on an empty stomach to take advantage of the fat-burning benefits of fasted training might notice additional benefits from using Burn Lab Pro.

Click Here for the Lowest Price on Burn Lab Pro

#4 PrimeShred: Best for Building Muscle


PrimeShred is the top-rated weight loss pill for men that want to lose fat while building muscle. Intense dieting and exercise can leave anyone feeling drained. For building muscle while losing weight, we chose PrimeShred, which stimulates the metabolism to burn fat by using thermogenic ingredients. 

In addition to being a thermogenic fat burner, PrimeShred contains ingredients that fuel your energy levels and sharpen your focus so you can endure demanding workouts. Brain-boosting compounds such as Rhodiola Rosea root also might help combat brain fog.

How it works

PrimeShred’s ingredients work on several levels, converting calories into energy faster to enhance workouts as well as tackling stubborn fat. It contains amino acids such as L-theanine, which may be able to reduce triglycerides, and L-tyrosine, which combines with other compounds and is thought to battle fat. It also contains green tea, capsaicin from cayenne pepper, and caffeine.

Overview of formula

In addition to several B vitamins to fire up the body’s calorie-converting energy, PrimeShred contains Rhodiola Rosea root, also known as golden root or arctic root, which people in cold regions of Asia and Europe have used to alleviate fatigue and adapt to stress. DMAE, a compound naturally produced in the body and found in fatty fish such as sardines, salmon, and anchovies, might help regulate brain function.

BioPerine, a patented extract from black pepper, might enhance digestion and the body’s nutrient absorption. To avoid the edge that some people feel after ingesting caffeine, PrimeShred also uses the amino acid L-theanine, found in green tea.


  • Green tea extract
  • Green coffee
  • Vitamins B3, B6, and B12
  • L-theanine
  • L-tyrosine
  • Caffeine anhydrous
  • Rhodiola Rosea root
  • Cayenne pepper
  • BioPerine
  • DMAE


The manufacturer recommends taking three pills about 20 minutes before breakfast on non-training and training days for the most effective results.

Who should take this product?

Men who want to shred fat without sacrificing energy or muscle mass might find the high-potency formula of PrimeShred beneficial.

Click Here for the Lowest Price on PrimeShred

#5 PhenGold: Best Appetite Suppressant For Men


PhenGold doubles down on your body’s natural fat-burning ability by suppressing hunger while increasing your metabolism. Although it uses B vitamins to reduce cravings, it also contains green coffee extract to boost metabolism, as well as other vitamins and nutrients that reduce inflammation and cholesterol.

How it works

PhenGold contains what its manufacturer calls “powerhouse weight loss ingredients”: green leaf tea, caffeine, and cayenne pepper, which some studies have shown may contribute to weight loss. To support a healthy metabolism, reduce fatigue, and help control appetite, PhenGold also contains vitamins B3, B6, and B12, which provide added benefits.

Overview of formula

Like other weight loss supplements, PhenGold’s ingredients complement different aspects of losing weight. For instance, caffeine, green coffee bean extract, and green tea extract decrease fatigue, increase concentration, and ramp up the body’s metabolism and fat-burning properties. Cayenne pepper promotes the body’s natural heat production or thermogenesis; studies show it also helps people feel fuller longer so that they experience fewer cravings.

Vitamin B3, or niacin, keeps the metabolism healthy while improving cardiovascular health, reducing LDL (or bad) cholesterol, and protecting insulin levels. Vitamins B6 and B12 also support a healthy metabolism, boosting energy and reducing fatigue.

Lastly, because people tend to eat more when they feel stressed, PhenGold includes ingredients that may help improve mood, memory, brain function, and alertness, such as DMAE, L-tyrosine, and L-theanine.


  • Green tea extract
  • Caffeine anhydrous
  • Cayenne pepper (capsicum annum)
  • Green coffee bean extract (chlorogenic acid)
  • Rhodiola Rosea root
  • Vitamin B3
  • Vitamin B6
  • Vitamin B12
  • L-theanine
  • L-tyrosine
  • Black pepper extract (piperine)
  • DMAE


The manufacturer recommends taking three capsules 20 minutes before breakfast, ideally before exercise.

Who should take this product?

PhenGold is the best weight loss pill for anyone that wants to increase metabolism, suppress appetite, and increase your body’s ability to burn fat. PhenGold is especially helpful for anyone that struggles with snacking and cravings.

Click Here for the Lowest Price on PhenGold

How We Chose the Best Fat Burners for Men

All fat burners claim to get you toned and ripped right away. However, because these products are not prescription weight loss pills but dietary supplements, the U.S. Food and Drug Administration is not authorized to review any of their claims about fat-burning capabilities and side effects before companies market them to the public.

Understandably, this makes the crowded market of fat loss pills confusing. That’s why we focused on the following factors.


Natural weight loss pills like the ones we’ve listed here have clinically dosed ingredients, including natural compounds such as fiber, green tea extract, and caffeine that researchers have studied repeatedly for their weight loss and fat loss benefits. We also like when a trusted fat burner lists the amount of each ingredient on the label.

Money-Back Guarantee

The best fat burner is designed to complement your regular exercise and diet, so some users might not see immediate results. Remember, even the best weight loss pill is not a “magic pill” that melts away pounds as you sleep. That’s why we prefer manufacturers who offer a money-back guarantee to dissatisfied customers. For instance, PhenQ has a 60-day money-back guarantee, so you’ll have two months to notice any results.

Servings Per Bottle

Similar to other diet supplements, fat burners have varying serving sizes. The best fat burner will list how many pills or capsules are in one serving. One bottle of a fat burner may contain 120 capsules, but if the manufacturer says to take those four times daily, you’ll need another bottle after one month. Consult your doctor if you’re unsure what dosage is right for you.

Customer Reviews

Endorsements from athletes such as MMA fighters are one thing. Reviews from everyday people happy with their weight loss and fat loss, especially belly fat, are another. We like products that include several customer reviews, including “before and after” photos where people explain how they worked the fat burner into their regular diet and exercise routine.


Fat burners are a maintenance product. Although you shouldn’t take fat burners as long as you take a daily vitamin, you will take them until you reach your ideal weight. With monthly prices ranging from $10 to $70 or more, we say the best fat burner combines effective ingredients with a price that fits into the average budget. Even better, some companies offer deals such as adding a free bottle with the purchase of two.

Shipping and Return Policy

Just as we appreciate companies that provide a money-back guarantee, we also read the fine print on the shipping and return policy. We think a fat burner isn’t worthwhile if it charges high shipping fees, which a customer then has to pay if they’re dissatisfied with the product.

How Do Weight Loss Pills Work to Help You Burn Fat?

Even the best fat burners and best weight loss pills aren’t magic potions. It’s best to think of them as weight management supplements.

Diet pills and fat burners work by increasing the body’s energy so that you burn stored fat and reduce the amount of fat available for storage. Using energy is part of our normal fat metabolism. Ingesting calories and supplements such as fatty acids (including Omega-3) give the heart, muscles, and organs energy. Any fatty acids that the body doesn’t use as energy become triglycerides or stored fat.

Men’s fat burners also promote fat burning by boosting your body’s capacity for harder workouts, so you feel less fatigue. Plus, they contain ingredients that might help restrict your body from creating new fat and suppress your cravings so that you don’t undo all your hard work by splurging on carbs, sugar, and fatty foods.

Bear in mind: Not all types of body fat are created equally, either. Fat burners and weight loss pills target white adipose tissue or white fat, the energy reserve our bodies create when we ingest too many calories. This dietary fat poses a metabolic risk when it collects around your abdominal area.

Brown adipose tissue, or brown fat, is the type of fat our bodies need to stay warm. (Newborns have a lot of it.) Scientists say that brown fat generates heat to warm us by burning calories. Experiments that add more brown fat to mice have found that they burn energy at a higher rate and reduce their overall fat, protecting them from diet-related obesity.

Do Men Lose Weight Differently Than Women?

Lots of weight loss pills and programs emphasize the fat metabolism differences between men and women, as well as men’s body weight compared to women’s. In general, men have more lean muscle tissue than body fat, burning more calories even when they’re at rest. That’s why when men and women cut the same number of calories from their daily intake, men seem to have more significant weight loss right away.

However, that’s just a fortunate side effect, dieticians say. Over the long haul, men and women who stick with a weight loss program that includes a low-fat diet and exercise have similar fat metabolism, studies show.

How Much Do Good Weight Loss Supplements Cost?

Prices for diet supplements vary widely. However, when compared with the cost of prescription weight loss drugs, they’re relatively inexpensive. One month’s supply of PhenGold costs $64.95 compared to the roughly $125 a month that you might spend on a prescription weight loss drug such as Orlistat (Xenical).

How Effective Are Weight Loss Pills?

We think that the best weight loss pills help you lose weight as part of an overall weight loss process. We’d all like to pop a pill and not think about ingesting fewer calories, low-fat foods, or extra sugar—or logging 20 to 30 minutes of exercise a day.

However, no weight loss drug or supplement works in a vacuum. We believe that if you incorporate a fat burner into a healthy diet and exercise regimen, you’ll notice that you’re burning fat at a higher rate and shedding pounds as well.

That said, the ingredients in some supplements might trigger side effects because of allergies or interactions with other medications or supplements. That might not happen for every customer, but it does occur. According to a study in the New England Journal of Medicine, adverse side effects from supplements caused about 23,000 annual emergency department visits over ten years.

Let’s look at something that seems as benign as coffee. Coffee is natural, and many of us can’t start the day without a cup. Retailers even sell jockey T-shirts and plaques with puns about how we can’t do without coffee. Yet, some people can’t tolerate coffee at all because of side effects such as insomnia.

If you notice that one cup of coffee makes you feel wired for hours, or if your doctor advises that you avoid caffeinated drinks because of how they affect your heart rate or blood pressure, you’ll want to note the weight loss pill ingredients carefully. You might want to choose a fat burner or diet pill that doesn’t contain coffee, caffeine, or similar stimulants.

How to Get the Best Results with Weight Loss Supplements 

Weight loss, just like weight gain, doesn’t happen overnight. As much as we wish we could melt away unwanted fat at the snap of our fingers, there’s no magic potion that makes fat disappear within days or a week. The manufacturers of the weight loss pills that we recommend all say that you won’t see results just by taking these pills.

According to Observer, weight loss pills need to be part of your regular diet and exercise routine to help you lose weight. We like to think of them as a weight loss support system, helping your fat loss as well as dropping pounds by making it easier to control your blood sugar levels, monitor your calorie intake, control your appetite, and burn more energy.

Things to Avoid When Buying Diet Pills for Men

Anyone dealing with stubborn or unexpected weight gain finds it difficult to resist claims that certain fat burner supplements make about giving you the cut body you’ve always wanted. But those claims can be flabby, too, if they have no substance. As you compare fat loss pills, watch for the following:

Aggressive Marketing Tactics: We appreciate it when companies share testimonials from satisfied customers or quotes from celebrities or athletes who endorse their product. But a weight loss pill shouldn’t ratchet up your sense of urgency that you’re missing out by not trying it.  

Proprietary Formulas: Some fat burners and weight loss pills, even among those we’ve chosen here, have proprietary or trademarked formulas. However, always check what’s in these compounds by looking at the label for the listed ingredients. A reputable weight loss pill will list ingredients so that users can avoid side effects due to interactions with other supplements or medications.

Too Many Stimulants: Green tea extract, coffee beans, coffee, and caffeine are all natural stimulants. While they don’t affect your heart rate or energy level in the same ways, stimulants can cause unpleasant side effects, especially alongside prescription medication. For instance, too much caffeine can cause headaches, seizures, insomnia, irregular heartbeat, and diarrhea.

Final Thoughts – Which Weight Loss Pill is Right for You?

Finding the best weight loss pill or fat burner for you depends on your weight loss goals and your current health. The fat burning supplements and weight loss pills we recommend here all cite studies related to the benefits of the natural ingredients that they use. However, the results of any fat burner or diet pill depend a lot on a person’s physiology and other factors.

We sympathize with how many people find losing weight such a challenge. Trying to eat healthy, tracking your calories, and fitting exercise into a busy day can add to your stress levels to the point that you’re watching every dip and rise of the scale. Ideally, weight loss should provide benefits that make you feel healthier and happier: more energy, more endurance, and a sexy, toned physique.

Perhaps you’ve never previously considered taking a diet pill or a fat burner, or maybe you’ve thought that taking a fat-burning supplement means that you can eat or drink whatever you like without packing on the pounds or experiencing other consequences.

While we hope that this guide helps you understand that these types of diet pills don’t work quite that way, we appreciate that testimonials show how people who have struggled to lose weight find some benefit in these products. The pills are most successful when incorporated into a balanced regimen.

We also hope that we’ve answered any questions you might have had about thermogenic fat burners so that you can choose the weight loss pill that will help you build the body you want and that aligns with your other fitness and lifestyle goals.


This article is provided by an advertiser. Statements made are not meant to offer medical advice nor to diagnose any condition. Any studies cited here may be preliminary, and may or may not be peer reviewed, and may or may not have sufficient participants to be statistically relevant. Anecdotal accounts should not be taken as scientific results. Products discussed in this article are not designed to diagnose, treat, prevent, or cure any disease. The FDA does not evaluate dietary supplements. Consult your doctor about possible interactions, allergies, and if you are considering using a natural and/or dietary supplements for any condition. Individual results will vary.

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